CJC-1295 no DAC

Description

CJC-1295 No DAC (Mod GRF 1-29) – Tetrasubstituted GHRH Receptor Agonist

Buy CJC-1295 No DAC in Canada – High-Purity Reference Standard for Somatotropic Pulsatility Research

CJC-1295 No DAC (Modified Growth Hormone-Releasing Factor 1-29) represents an optimized fragment of native GHRH(1-44). The native peptide undergoes rapid enzymatic degradation, primarily via DPP-4 cleavage at the N-terminus, resulting in a biological half-life of only a few minutes. By substituting four specific residues—$\text{D-Ala}^2$, $\text{Gln}^8$, $\text{Ala}^{15}$, and $\text{Leu}^{27}$—Mod GRF 1-29 achieves markedly enhanced metabolic stability and enzymatic resistance while retaining full biological affinity for the pituitary GHRH receptor. Unlike long-acting formulations conjugated with a Drug Affinity Complex (DAC), CJC-1295 No DAC features a shorter, physiological clearance profile (approximately 30 minutes in biological models). This allows researchers to stimulate discrete, pulsatile somatotropic secretion that mimics natural physiological bursts rather than continuous baseline elevation. For Canadian academic institutions, analytical laboratories, and biotechnology facilities investigating somatotropic signaling kinetics, cellular repair pathways, and growth factor transcription, North Vital Labs supplies analytical-grade CJC-1295 No DAC backed by comprehensive third-party testing.

Primary Research Applications

• GHRH Receptor Binding & Signal Cascades: Serves as a standard molecular tool to analyze $G\alpha_s$-coupled adenylyl cyclase activation, intracellular $cAMP$ accumulation, and protein kinase A (PKA) signaling in pituitary cell lines.

• Pulsatile Somatotropic Secretion Kinetics: Facilitates laboratory evaluation of episodic, pulse-like growth hormone release profiles while preserving natural negative feedback mechanisms.

• Peptidase Resistance & Half-Life Optimization: Widely utilized in peptide chemistry assays to compare enzymatic degradation kinetics against native linear GHRH fragments under DPP-4 exposure.

• Synergistic Secretagogue Cross-Talk: Enables controlled observation of receptor cooperativity when co-incubated with ghrelin-receptor agonists (GHS-Rs) such as Ipamorelin or GHRP-2 to evaluate amplified endocrine response models.

Why Canadian Researchers Choose North Vital Labs

• 100% Domestic Canadian Fulfillment: Shipments originate directly within Canada, guaranteeing zero customs hold-ups, border clearance delays, or unexpected import tariffs.

• HPLC Lab-Verified Purity: Each lot undergoes rigorous third-party analytical testing to ensure 99%+ chemical purity, complete with accessible Certificates of Analysis (COAs).

• Direct Domestic Checkout: Seamless ordering supported by established Canadian payment methods, including Interac e-Transfer.

• Discreet Express Delivery: Shipped across Canada in protective, temperature-stable packaging with live tracking provided upon dispatch.

Compound Specifications

• Molecular Name: CJC-1295 No DAC (Modified GRF 1-29 / Tetrasubstituted GHRH 1-29)

• Molecular Formula: $\text{C}_{152}\text{H}_{252}\text{N}_{44}\text{O}_{42}$

• Form: Lyophilized white powder (freeze-dried cake)

• Purity: 99%+ (HPLC lab-verified)

• Storage Protocol: Store lyophilized powder in a cool, dry place shielded from direct light (refrigerate at 2°C–8°C once reconstituted).

• Compliance Statement: Exclusively intended for laboratory research and in vitro/in vivo scientific evaluation. Not for human, clinical, or veterinary applications. This compound has not been evaluated or approved by Health Canada.