NAD+

Description

NAD+ – Essential Cellular Coenzyme & Redox Signaling Standard

Buy NAD+ in Canada – High-Purity Reference Compound for Metabolic & Sirtuin Research

$\beta$-Nicotinamide Adenine Dinucleotide (NAD+) is an essential pyridine nucleotide coenzyme central to energy metabolism and intracellular signaling. In metabolic pathways, NAD+ acts as an obligate electron acceptor in glycolysis, $\beta$-oxidation, and the tricarboxylic acid (TCA) cycle, facilitating mitochondrial ATP generation via oxidative phosphorylation. Beyond its role as a metabolic cofactor, NAD+ functions as a rate-limiting co-substrate for key regulatory enzymes—including the sirtuin family of protein deacylases, PARP DNA repair enzymes, and cyclic ADP-ribose synthases (CD38/CD157). For Canadian research institutions, biotechnology firms, and academic laboratories investigating cellular senescence, metabolic homeostasis, and genomic stability mechanisms, North Vital Labs supplies analytical-grade NAD+ backed by comprehensive third-party testing.

Primary Research Applications

• Mitochondrial Bioenergetics & Redox Kinetics: Serves as a standard molecular benchmark for measuring cellular $\text{NAD}^+/\text{NADH}$ ratios, electron transport efficiency, and oxidative phosphorylation capacity in isolated mitochondrial systems.

• Sirtuin Deacetylase Pathway Activation: Facilitates laboratory evaluation of SIRT1, SIRT3, and SIRT6 enzymatic activation, histone deacetylation, and downstream transcriptional regulation of metabolic genes.

• PARP-Mediated DNA Repair Cascades: Utilized in cellular damage models to analyze poly(ADP-ribosyl)ation kinetics, chromatin remodeling, and DNA single-strand break repair mechanisms.

• Cellular Senescence & Ectoenzyme Signaling: Enables controlled observation of age-related NAD+ depletion pathways, including CD38 enzymatic consumption and chronic inflammatory metabolic flux.

Why Canadian Researchers Choose North Vital Labs

• 100% Domestic Canadian Fulfillment: Shipments originate directly within Canada, guaranteeing zero customs delays, border clearance hold-ups, or unexpected import duties.

• HPLC Lab-Verified Purity: Each lot undergoes rigorous independent analytical testing to confirm 99%+ chemical purity, accompanied by verifiable Certificates of Analysis (COAs).

• Direct Domestic Checkout: Seamless and secure order clearance supported by standard Canadian payment options, including Interac e-Transfer.

• Discreet Express Delivery: Shipped across Canada in protective, temperature-stable packaging with live tracking provided immediately upon dispatch.

Compound Specifications

• Molecular Name: $\beta$-Nicotinamide Adenine Dinucleotide (NAD+, Oxidized Form)

• Form: Lyophilized white powder (freeze-dried cake)

• Purity: 99%+ (HPLC lab-verified)

• Storage Protocol: Store lyophilized powder in a cool, dry place away from direct light (refrigerate at 2°C–8°C once reconstituted).

• Compliance Statement: Exclusively intended for laboratory research and in vitro/in vivo scientific evaluation. Not for human, clinical, or veterinary applications. This product has not been evaluated or approved by Health Canada.