HGH 36 IU

Description

HGH 36 IU (Somatropin) – Recombinant Human Growth Hormone Standard

Buy HGH in Canada – High-Purity Reference Standard for GHR Signaling & Somatotropic Research

Recombinant Human Growth Hormone (Somatropin, 191 amino acids) is synthesized to match the exact primary amino acid sequence and tertiary conformation of native pituitary-derived human growth hormone, featuring two internal disulfide bridges ($\text{Cys}^{53}\text{–Cys}^{165}$ and $\text{Cys}^{182}\text{–Cys}^{189}$). Upon binding to the extracellular domain of the transmembrane growth hormone receptor (GHR), it induces receptor homodimerization, triggering the transphosphorylation of receptor-associated Janus kinase 2 (JAK2). This activation initiates downstream phosphorylation of signal transducer and activator of transcription 5b (STAT5b), promoting the nuclear translocation of transcription factors responsible for hepatic IGF-1 expression and cellular proliferation markers. Beyond the JAK/STAT pathway, somatropin standard formulations are utilized to analyze MAPK/ERK and PI3K/Akt signaling cascades involved in lipid turnover, cellular protein synthesis kinetics, and carbohydrate metabolism dynamics. For Canadian academic institutions, analytical laboratories, and biotechnology groups investigating endocrine receptor binding, somatotropic axis modeling, and growth factor gene expression, North Vital Labs supplies analytical-grade HGH 36 IU backed by comprehensive third-party testing.

Primary Research Applications

• GHR Dimerization & Signal Transduction: Serves as a primary reference standard for measuring GHR binding affinity, JAK2 kinase autophosphorylation, and STAT5b nuclear translocation dynamics.

• Hepatic IGF-1 Transcription Kinetics: Facilitates laboratory evaluation of growth hormone-mediated induction of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 3 (IGFBP-3) mRNA expression.

• Metabolic Substrate Utilization Pathways: Utilized to analyze cellular lipid mobilization via hormone-sensitive lipase (HSL) upregulation and insulin receptor cross-talk in adipocyte and hepatocyte cell lines.

• Cellular Protein Synthesis & Nitrogen Retention Models: Enables controlled observation of amino acid uptake mechanisms, ribosomal translation efficiency, and skeletal muscle cell hypertrophy signaling.

Why Canadian Researchers Choose North Vital Labs

• 100% Domestic Canadian Fulfillment: Shipments originate directly within Canada, guaranteeing zero customs hold-ups, border clearance delays, or unexpected import tariffs.

• HPLC Lab-Verified Purity & Potency: Each lot undergoes rigorous third-party analytical testing to confirm 99%+ sequence purity and exact IU biological activity, accompanied by accessible Certificates of Analysis (COAs).

• Direct Domestic Checkout: Seamless ordering supported by established Canadian payment methods, including Interac e-Transfer.

• Discreet Express Delivery: Shipped across Canada in protective, temperature-stable packaging with live tracking provided upon dispatch.

Compound Specifications

• Molecular Name: Somatropin (Recombinant Human Growth Hormone / 191 Amino Acid Polypeptide)

• Potency / Quantity: 36 IU (~12mg) per vial

• Molecular Formula: $\text{C}_{990}\text{H}_{1528}\text{N}_{262}\text{O}_{300}\text{S}_{7}$

• Form: Lyophilized white powder (freeze-dried cake)

• Purity: 99%+ (HPLC lab-verified)

• Storage Protocol: Store lyophilized powder in a cool, dry place shielded from direct light (refrigerate at 2°C–8°C once reconstituted; handle gently to avoid shear degradation).

• Compliance Statement: Exclusively intended for laboratory research and in vitro/in vivo scientific evaluation. Not for human, clinical, or veterinary applications. This compound has not been evaluated or approved by Health Canada.